| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.112ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This SLC1A5 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | SLC1A5 |
| Gene ID: | 6510 |
| Uniprot ID: | AAAT_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Expressed in CD34-positive hematopoietic progenitors (at protein level). |
| Post Translational Modifications | |
| Function | Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation. The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system. Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons. Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. |
| Protein Name | Neutral Amino Acid Transporter B(0 Atb(0 Baboon M7 Virus Receptor Rd114/Simian Type D Retrovirus Receptor Sodium-Dependent Neutral Amino Acid Transporter Type 2 Solute Carrier Family 1 Member 5 |
| Database Links | Reactome: R-HSA-352230 Reactome: R-HSA-9013149 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative ELISA Names | Neutral Amino Acid Transporter B(0 ELISA kit Atb(0 ELISA kit Baboon M7 Virus Receptor ELISA kit Rd114/Simian Type D Retrovirus Receptor ELISA kit Sodium-Dependent Neutral Amino Acid Transporter Type 2 ELISA kit Solute Carrier Family 1 Member 5 ELISA kit SLC1A5 ELISA kit ASCT2 ELISA kit M7V1 ELISA kit RDR ELISA kit RDRC ELISA kit |
| output |
Information sourced from Uniprot.org
