Function | Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable). |
Protein Name | Monocarboxylate Transporter 8Mct 8Monocarboxylate Transporter 7Mct 7Solute Carrier Family 16 Member 2X-Linked Pest-Containing Transporter |
Database Links | Reactome: R-HSA-879518 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
Alternative Protein Names | Monocarboxylate Transporter 8 proteinMct 8 proteinMonocarboxylate Transporter 7 proteinMct 7 proteinSolute Carrier Family 16 Member 2 proteinX-Linked Pest-Containing Transporter proteinSLC16A2 proteinMCT7 proteinMCT8 proteinXPCT protein |
Information sourced from Uniprot.org