Human SLC12A5/KCC2 protein (Recombinant) (N-His) (STJP008412)

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STJP008412
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC12A5/KCC2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SLC12A5
Gene ID: 57468
Uniprot ID: S12A5_HUMAN
Immunogen Region: Lys653-Lys967
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated at Thr-929 and Thr-1030 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity.
Function Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.
Protein Name Solute Carrier Family 12 Member 5
Electroneutral Potassium-Chloride Cotransporter 2
K-Cl Cotransporter 2
Hkcc2
Neuronal K-Cl Cotransporter
Database Links Reactome: R-HSA-426117
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendrite
Detected On Dendrites
But Not On Axons Of Spinal Cord Neurons And At Gphn-Positive Inhibitory Synapses
Alternative Protein Names Solute Carrier Family 12 Member 5 protein
Electroneutral Potassium-Chloride Cotransporter 2 protein
K-Cl Cotransporter 2 protein
Hkcc2 protein
Neuronal K-Cl Cotransporter protein
SLC12A5 protein
KCC2 protein
KIAA1176 protein

Information sourced from Uniprot.org

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