Human SLC10A1 protein (Recombinant) (N-His-SUMO) (STJP009304)

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STJP009304
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC10A1-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SLC10A1
Gene ID: 6554
Uniprot ID: NTCP_HUMAN
Immunogen Region: Phe244-Phe284
Immunogen: Homo sapiens (Human)
Function As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It is strictly dependent on the extracellular presence of sodium. It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate. Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation. (Microbial infection) Acts as a receptor for hepatitis B virus.
Protein Name Hepatic Sodium/Bile Acid Cotransporter
Cell Growth-Inhibiting Gene 29 Protein
Na(+/Bile Acid Cotransporter
Na(+/Taurocholate Transport Protein
Sodium/Taurocholate Cotransporting Polypeptide
Ntcp
Solute Carrier Family 10 Member 1
Slc10a1
Database Links Reactome: R-HSA-159418
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Hepatic Sodium/Bile Acid Cotransporter protein
Cell Growth-Inhibiting Gene 29 Protein protein
Na(+/Bile Acid Cotransporter protein
Na(+/Taurocholate Transport Protein protein
Sodium/Taurocholate Cotransporting Polypeptide protein
Ntcp protein
Solute Carrier Family 10 Member 1 protein
Slc10a1 protein
SLC10A1 protein
NTCP protein
GIG29 protein

Information sourced from Uniprot.org