Human SLBP protein (Recombinant) (N-His) (STJP015921)

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STJP015921
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Short Description :Recombinant-Human SLBP-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:Please contact us for further information.
Gene Symbol:SLBP
Gene ID:7884
Uniprot ID:SLBP_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Cys72-Asp198
Post Translational Modifications Phosphorylated on Thr-61 and Thr-62 in the S-phase. Phosphorylation of Thr-62 by CDK1 primes phosphorylation of Thr-61 by CK2. Phosphorylation of Thr-62 is required for its degradation by the proteasome at the end of the S phase. Its degradation is not required for histone mRNA degradation at the end of the S phase. All the phosphorylated forms detected are present in the cytoplasm. Both unphosphorylated and phosphorylated forms bind the stem-loop structure of histone mRNAs. Phosphorylation at Thr-171 increases affinity for histone mRNAs. Ubiquitinated by the CRL2(FEM1A), CRL2(FEM1B) and CRL2(FEM1C) complexes, leading to its degradation.
Function RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs.
Protein Name Histone Rna Hairpin-Binding Protein
Histone Stem-Loop-Binding Protein
Database Links Reactome: R-HSA-159230
Reactome: R-HSA-73856
Reactome: R-HSA-77588
Cellular Localisation Cytoplasm
Nucleus
Polyribosome-Associated
Localizes Predominantly In The Nucleus At The G1/G2 Phases And The Beginning Of S Phase
Through The S Phase
Partially Redistributes To The Cytoplasm
Binding To Histone Mrna Is Necessary For Cytoplasmic Localization
Shuttles Between The Nucleus And The Cytoplasm
Imported In The Nucleus By The Importin Alpha/Importin Beta Receptor
Alternative Protein Names Histone Rna Hairpin-Binding Protein protein
Histone Stem-Loop-Binding Protein protein
SLBP protein
HBP protein

Information sourced from Uniprot.org

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