Human SIRP-alpha/CD172a protein (Recombinant) (C-hFc & His) (STJP002591)

SKU:
STJP002591

£72.50 - £223.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human SIRP-alpha/CD172a-C-hFc & His protein was developed from hek293 cells and has a target region of C-hFc & His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: 1.Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human CD47 at 1 Mu g/mL (100 Mu L/well) can bind Recombinant Human SIRP alpha with a linear range of 1-6 ng/mL.2.Loaded Human SIRP-alpha/CD172a Protein, C-hFc&His (Catal
Gene Symbol: SIRPA
Gene ID: 140885
Uniprot ID: SHPS1_HUMAN
Immunogen Region: Glu31-Arg370
Immunogen: Recombinant Human SIRP-alpha/CD172a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu31-Arg370) of human SIRP alpha/CD172a (Accession #NP_542970.1) fused with an Fc, 6×His tag at the C-terminus.
Post Translational Modifications N-glycosylated. Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
Function Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production.
Protein Name Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1
Shp Substrate 1
Shps-1
Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs
Bit
Cd172 Antigen-Like Family Member A
Inhibitory Receptor Shps-1
Macrophage Fusion Receptor
Myd-1 Antigen
Signal-Regulatory Protein Alpha-1
Sirp-Alpha-1
Signal-Regulatory Protein Alpha-2
Sirp-Alpha-2
Signal-Regulatory Protein Alpha-3
Sirp-Alpha-3
P84
Cd Antigen Cd172a
Database Links Reactome: R-HSA-202733
Reactome: R-HSA-391160
Reactome: R-HSA-6798695
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 protein
Shp Substrate 1 protein
Shps-1 protein
Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs protein
Bit protein
Cd172 Antigen-Like Family Member A protein
Inhibitory Receptor Shps-1 protein
Macrophage Fusion Receptor protein
Myd-1 Antigen protein
Signal-Regulatory Protein Alpha-1 protein
Sirp-Alpha-1 protein
Signal-Regulatory Protein Alpha-2 protein
Sirp-Alpha-2 protein
Signal-Regulatory Protein Alpha-3 protein
Sirp-Alpha-3 protein
P84 protein
Cd Antigen Cd172a protein
SIRPA protein
BIT protein
MFR protein
MYD1 protein
PTPNS1 protein
SHPS1 protein
SIRP protein

Information sourced from Uniprot.org

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