Human SIGLEC11 protein (Recombinant) (C-Fc) (STJP008649)

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STJP008649
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SIGLEC11-C-Fc protein was developed from mammalian cells and has a target region of C-Fc. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SIGLEC11
Gene ID: 114132
Uniprot ID: SIG11_HUMAN
Immunogen Region: Asn29-Glu554
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on tyrosine residues.
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Protein Name Sialic Acid-Binding Ig-Like Lectin 11
Sialic Acid-Binding Lectin 11
Siglec-11
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Sialic Acid-Binding Ig-Like Lectin 11 protein
Sialic Acid-Binding Lectin 11 protein
Siglec-11 protein
SIGLEC11 protein
UNQ9222 protein
PRO28718 protein

Information sourced from Uniprot.org

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