| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/ug of the protein by LAL method. |
| Gene Symbol: | SIGLEC6 |
| Gene ID: | 946 |
| Uniprot ID: | SIGL6_HUMAN |
| Immunogen Region: | Gln27-Val331 |
| Immunogen: | Recombinant Human siglec 6 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Gln27-Val331) of Human siglec 6 fused with a His tag and Avi tag at the C-terminal. |
| Immunogen Sequence: | QERRFQLEGPESLTVQEGLC VLVPCRLPTTLPASYYGYGY WFLEGADVPVATNDPDEEVQ EETRGRFHLLWDPRRKNCSL SIRDARRRDNAAYFFRLKSK WMKYGYTSSKLSVRVMALTH RPNISIPGTLESGHPSNLTC SVPWVCEQGTPPIFSWMSAA PTSLGPRTTQSSVLTITPRP QDHSTNLTCQVTFPGAGVTM ERTIQLNVSSFKILQNTSSL PVLEGQALRLLCDADGNPP |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 6Siglec-6Cd33 Antigen-Like 1Cdw327Obesity-Binding Protein 1Ob-Bp1Cd Antigen Cd327 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Sialic Acid-Binding Ig-Like Lectin 6 proteinSiglec-6 proteinCd33 Antigen-Like 1 proteinCdw327 proteinObesity-Binding Protein 1 proteinOb-Bp1 proteinCd Antigen Cd327 proteinSIGLEC6 proteinCD33L proteinCD33L1 proteinOBBP1 protein |
Information sourced from Uniprot.org
