Human Siglec-5/CD170 protein (Recombinant) (C-His&Avi) {Biotin} (STJP019850)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human Siglec-5/CD170 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu17-Thr434) of Human Siglec-5/CD170 (Accession #O15389) fused with a C-His&Avi tag at the C-terminus
General Information
| Short Description | Recombinant-Human Siglec-5/CD170-C-His&Avi protein was developed in hek293 cells using the region Glu17-Thr434. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS, 350 mM NaCl (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | SIGLEC5 |
| Gene ID | 8778 |
| Uniprot ID | SIGL5_HUMAN |
| Immunogen | Biotinylated Recombinant Human Siglec-5/CD170 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu17-Thr434) of Human Siglec-5/CD170 (Accession #O15389) fused with a C-His&Avi tag at the C-terminus |
| Immunogen Region | Glu17-Thr434 |
| Immunogen Sequence | EKPVYELQVQKSVTVQEGLC VLVPCSFSYPWRSWYSSPPL YVYWFRDGEIPYYAEVVATN NPDRRVKPETQGRFRLLGDV QKKNCSLSIGDARMEDTGSY FFRVERGRDVKYSYQQNKLN LEVTALIEKPDIHFLEPLES GRPTRLSCSLPGSCEAGPPL TFSWTGNALSPLDPETTRSS ELTLTPRPEDHGTNLTCQMK RQGAQVTTERTVQLNVSYAP QTITIFRNGIALEILQNTS |
Additional Info
| Tissue Specificity | Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 5Siglec-5Cd33 Antigen-Like 2Obesity-Binding Protein 2Ob-Bp2Ob-Binding Protein 2Cd Antigen Cd170 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Sialic Acid-Binding Ig-Like Lectin 5 proteinSiglec-5 proteinCd33 Antigen-Like 2 proteinObesity-Binding Protein 2 proteinOb-Bp2 proteinOb-Binding Protein 2 proteinCd Antigen Cd170 proteinSIGLEC5 proteinCD33L2 proteinOBBP2 protein |
Information sourced from Uniprot.org