| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, 300mM NaCl, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit Anti-CD3-induced proliferation of jurkat cells. The ED50 for this effect is 1.8-7.2 Mu g/mL. |
| Gene Symbol: | SIGLEC15 |
| Gene ID: | 284266 |
| Uniprot ID: | SIG15_HUMAN |
| Immunogen Region: | Phe20-Thr263 |
| Immunogen: | Recombinant Human Siglec-15/CD33L3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe20-Thr263) of human Siglec-15/CD33L3 (Accession #NP_998767.1) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | FVRTKIDTTENLLNTEVHSS PAQRWSMQVPPEVSAEAGDA AVLPCTFTHPHRHYDGPLTA IWRAGEPYAGPQVFRCAAAR GSELCQTALSLHGRFRLLGN PRRNDLSLRVERLALADDRR YFCRVEFAGDVHDRYESRHG VRLHVTAAPRIVNISVLPSP AHAFRALCTAEGEPPPALAW SGPALGNSLAAVRSPREGHG HLVTAELPALTHDGRYTCTA ANSLGRSEASVYLFRFHGA |
| Function | Binds sialylated glycoproteins. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 15Siglec-15Cd33 Antigen-Like 3 |
| Database Links | Reactome: R-HSA-2172127 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Sialic Acid-Binding Ig-Like Lectin 15 proteinSiglec-15 proteinCd33 Antigen-Like 3 proteinSIGLEC15 proteinCD33L3 protein |
Information sourced from Uniprot.org