Human SIGIRR protein (Recombinant) (N-His) (STJP005580)

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STJP005580
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SIGIRR-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SIGIRR
Gene ID: 59307
Uniprot ID: SIGIR_HUMAN
Immunogen Region: Met1-His118
Immunogen: Homo sapiens (Human)
Function Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Protein Name Single Ig Il-1-Related Receptor
Single Ig Il-1r-Related Molecule
Single Immunoglobulin Domain-Containing Il1r-Related Protein
Toll/Interleukin-1 Receptor 8
Tir8
Database Links Reactome: R-HSA-166058
Reactome: R-HSA-9008059
Cellular Localisation Membrane
Single-Pass Type Iii Membrane Protein
Alternative Protein Names Single Ig Il-1-Related Receptor protein
Single Ig Il-1r-Related Molecule protein
Single Immunoglobulin Domain-Containing Il1r-Related Protein protein
Toll/Interleukin-1 Receptor 8 protein
Tir8 protein
SIGIRR protein
UNQ301 protein
PRO342 protein

Information sourced from Uniprot.org

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