Human SHMT2 protein (Recombinant) (N-His) (STJP004588)

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STJP004588
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SHMT2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SHMT2
Gene ID: 6472
Uniprot ID: GLYM_HUMAN
Immunogen Region: Asn30-His504
Immunogen: Homo sapiens (Human)
Function Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate.5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.
Protein Name Serine Hydroxymethyltransferase - Mitochondrial
Shmt
Glycine Hydroxymethyltransferase
Serine Methylase
Database Links Reactome: R-HSA-196757
Reactome: R-HSA-9013408
Reactome: R-HSA-9837999
Cellular Localisation Mitochondrion
Mitochondrion Matrix
Mitochondrion Nucleoid
Mitochondrion Inner Membrane
Cytoplasm
Nucleus
Mainly Localizes In The Mitochondrion
Also Found In The Cytoplasm And Nucleus As Part Of The Brisc Complex
Alternative Protein Names Serine Hydroxymethyltransferase - Mitochondrial protein
Shmt protein
Glycine Hydroxymethyltransferase protein
Serine Methylase protein
SHMT2 protein

Information sourced from Uniprot.org