| Post Translational Modifications | Monoubiquitinated by CBL and CBLB after EGF stimulation.probably on its C-terminus. |
| Function | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion.promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation. |
| Protein Name | Sh3 Domain-Containing Kinase-Binding Protein 1Cd2-Binding Protein 3Cd2bp3Cbl-Interacting Protein Of 85 KdaHuman Src Family Kinase-Binding Protein 1Hsb-1 |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8866376Reactome: R-HSA-8875360Reactome: R-HSA-9679191Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmCytoskeletonCytoplasmic Vesicle MembranePeripheral Membrane ProteinSynapseSynaptosomeCell JunctionFocal AdhesionLocalized In Endocytic Vesicles Containing Clustered ReceptorsColocalizes With Asap1 In Vesicular StructuresColocalized With Actin Microfilaments And Focal AdhesionsColocalized With Magi2 In SynaptosomesTranslocation To Egfr Containing Vesicles Upon Egf Stimulation Is Inhibited In The Presence Of Sh3kbp1Colocalizes With Zfp36 In The Cytoplasm |
| Alternative Protein Names | Sh3 Domain-Containing Kinase-Binding Protein 1 proteinCd2-Binding Protein 3 proteinCd2bp3 proteinCbl-Interacting Protein Of 85 Kda proteinHuman Src Family Kinase-Binding Protein 1 proteinHsb-1 proteinSH3KBP1 proteinCIN85 protein |
Information sourced from Uniprot.org
