Human SGK2 protein (Recombinant) (N-His) (STJP006020)

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STJP006020
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SGK2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SGK2
Gene ID: 10110
Uniprot ID: SGK2_HUMAN
Immunogen Region: Thr40-Leu311
Immunogen: Homo sapiens (Human)
Post Translational Modifications Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193.
Function Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
Protein Name Serine/Threonine-Protein Kinase Sgk2
Serum/Glucocorticoid-Regulated Kinase 2
Database Links Reactome: R-HSA-2672351
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Serine/Threonine-Protein Kinase Sgk2 protein
Serum/Glucocorticoid-Regulated Kinase 2 protein
SGK2 protein

Information sourced from Uniprot.org

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