| Function | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B6 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Within the 17S U2 SnRNP complex, SF3B6 directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. SF3B6 stabilizes the intron branch site-U2 snRNA duplex, thereby promoting-binding of introns with poor sequence complementarity. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. |
| Protein Name | Splicing Factor 3b Subunit 6Pre-Mrna Branch Site Protein P14Sf3b 14 Kda SubunitSf3b14aSpliceosome-Associated Protein - 14-KdaSplicing Factor 3b - Subunit 6 - 14kda |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Splicing Factor 3b Subunit 6 proteinPre-Mrna Branch Site Protein P14 proteinSf3b 14 Kda Subunit proteinSf3b14a proteinSpliceosome-Associated Protein - 14-Kda proteinSplicing Factor 3b - Subunit 6 - 14kda proteinSF3B6 proteinSAP14 proteinSF3B14 proteinSF3B14A proteinCGI-110 proteinHSPC175 proteinHT006 protein |
Information sourced from Uniprot.org
