| Post Translational Modifications | Ubiquitinated. Sumoylated preferentially with SUMO2 or SUMO3. |
| Function | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination. Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage. Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription. Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis. |
| Protein Name | Probable Helicase SenataxinAmyotrophic Lateral Sclerosis 4 ProteinSen1 HomologSenataxin |
| Cellular Localisation | NucleusNucleoplasmNucleolusCytoplasmChromosomeTelomereCell ProjectionAxonGrowth ConeMay Be Detected In The Nucleolus Only In Cycling CellsAt Pachytene StageColocalizes Predominantly To The Heterochromatic Xy-Body Of Sex Chromosomes With Dna Damage Response Proteins In A Brca1-Dependent MannerLocalizes With Telomeric Dna In A Transcription-Dependent MannerUnder Replication StressColocalizes With A Variety Of Dna Damage Signaling And Repair Response Proteins At Distinct Nuclear Foci In Mitotic S/G2- And G1-Phase Cells In A Transcription- And Rna/Dna Hybrid-Dependent MannerLocalizes At Limited Number Of Nuclear FociColocalizes With Exosc9 In Nuclear Foci Upon Induction Of Transcription-Related Dna Damage At The S PhaseMost Abundant In The NucleusDetected In GranulesColocalized In Cycling Cells With Fbl In The Nucleolus |
| Alternative Protein Names | Probable Helicase Senataxin proteinAmyotrophic Lateral Sclerosis 4 Protein proteinSen1 Homolog proteinSenataxin proteinSETX proteinALS4 proteinKIAA0625 proteinSCAR1 protein |
Information sourced from Uniprot.org
