Human SETD7 protein (Recombinant) (N-His) (STJP008962)

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STJP008962
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SETD7-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SETD7
Gene ID: 80854
Uniprot ID: SETD7_HUMAN
Immunogen Region: Met1-Lys366
Immunogen: Homo sapiens (Human)
Function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS.
Protein Name Histone-Lysine N-Methyltransferase Setd7
Histone H3-K4 Methyltransferase Setd7
H3-K4-Hmtase Setd7
Lysine N-Methyltransferase 7
Set Domain-Containing Protein 7
Set7/9
Database Links Reactome: R-HSA-3214841
Cellular Localisation Nucleus
Chromosome
Alternative Protein Names Histone-Lysine N-Methyltransferase Setd7 protein
Histone H3-K4 Methyltransferase Setd7 protein
H3-K4-Hmtase Setd7 protein
Lysine N-Methyltransferase 7 protein
Set Domain-Containing Protein 7 protein
Set7/9 protein
SETD7 protein
KIAA1717 protein
KMT7 protein
SET7 protein
SET9 protein

Information sourced from Uniprot.org

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