SDS-PAGE gel of recombinant human Serpin D1 Heparin cofactor II protein under reducing conditions

Human Serpin D1/Heparin cofactor II protein (Recombinant) (His-Tag) (STJP018861)

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STJP018861
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Short Description :Recombinant-Human Serpin D1/Heparin cofactor II-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SERPIND1
Gene ID:3053
Uniprot ID:HEP2_HUMAN
Accession Number:NP_000176
Immunogen:Human
Immunogen Region:58-499aa
Immunogen Sequence:DFHKENT VTNDWIPEGE EDDDYLDLEK IFSEDDDYID IVDSLSVSPT DSDVSAGNIL QLFHGKSRIQ RLNILNAKFA FNLYRVLKDQ VNTFDNIFIA PVGISTAMGM ISLGLKGETH EQVHSILHFK DFVNASSKYE ITTIHNLFRK LTHRLFRRNF GYTLRSVNDL YIQKQFPILL DFKTKVREYY FAEAQIADFS DPAFIS
Tissue Specificity Expressed predominantly in liver. Also present in plasma. Isoform 2: Expressed in plasma (at protein level). Expressed in liver.
Post Translational Modifications Phosphorylated by FAM20C in the extracellular medium.
Function Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. Isoform 2: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro.
Protein Name Heparin Cofactor 2
Heparin Cofactor Ii
Hc-Ii
Protease Inhibitor Leuserpin-2
Hls2
Serpin D1
Database Links Reactome: R-HSA-140837
Reactome: R-HSA-140875
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation
Alternative Protein Names Heparin Cofactor 2 protein
Heparin Cofactor Ii protein
Hc-Ii protein
Protease Inhibitor Leuserpin-2 protein
Hls2 protein
Serpin D1 protein
SERPIND1 protein
HCF2 protein

Information sourced from Uniprot.org

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