| Function | Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection. |
| Protein Name | Sentrin-Specific Protease 2Axam2Smt3-Specific Isopeptidase 2Smt3ip2Sentrin/Sumo-Specific Protease Senp2 |
| Database Links | Reactome: R-HSA-3065679 |
| Cellular Localisation | NucleusNuclear Pore ComplexNucleus MembranePeripheral Membrane ProteinNucleoplasmic SideCytoplasmShuttles Between Cytoplasm And Nucleus |
| Alternative Protein Names | Sentrin-Specific Protease 2 proteinAxam2 proteinSmt3-Specific Isopeptidase 2 proteinSmt3ip2 proteinSentrin/Sumo-Specific Protease Senp2 proteinSENP2 proteinKIAA1331 protein |
Information sourced from Uniprot.org
