| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | Please contact us for more information. |
| Immunoreactivity: | Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 104cells/well are added to human E-Selectin/His Chimera coated plates (2 Mu g/mL with 100 Mu L/well) , approximately 40-50% |
| Gene Symbol: | SELE |
| Gene ID: | 6401 |
| Uniprot ID: | LYAM2_HUMAN |
| Immunogen: | Recombinant Human SELE/E-selectin/CD62E Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Trp22-Pro556) of human E-Selectin/CD62E (Accession #NP_000441.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | WSYNTSTEAMTYDEASAYCQ QRYTHLVAIQNKEEIEYLNS ILSYSPSYYWIGIRKVNNVW VWVGTQKPLTEEAKNWAPGE PNNRQKDEDCVEIYIKREKD VGMWNDERCSKKKLALCYTA ACTNTSCSGHGECVETINNY TCKCDPGFSGLKCEQIVNCT ALESPEHGSLVCSHPLGNFS YNSSCSISCDRGYLPSSMET MQCMSSGEWSAPIPACNVVE CDAVTNPANGFVECFQNPG |
| Function | Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. |
| Protein Name | E-SelectinCd62 Antigen-Like Family Member EEndothelial Leukocyte Adhesion Molecule 1Elam-1Leukocyte-Endothelial Cell Adhesion Molecule 2Lecam2Cd Antigen Cd62e |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | E-Selectin proteinCd62 Antigen-Like Family Member E proteinEndothelial Leukocyte Adhesion Molecule 1 proteinElam-1 proteinLeukocyte-Endothelial Cell Adhesion Molecule 2 proteinLecam2 proteinCd Antigen Cd62e proteinSELE proteinELAM1 protein |
Information sourced from Uniprot.org