Human SEC61B protein (Recombinant) (His-Tag) (STJP018554)

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STJP018554
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SEC61B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 2mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: SEC61B
Gene ID: 10952
Uniprot ID: SC61B_HUMAN
Immunogen Region: 1-70aa
Accession Number: NP_006799
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSMPGPTPS GTNVGSSGRS PSKAVAARAA GSTVRQRKNA SCGTRSAGRT TSAGTGGMWR FYTEDSPGLK VGP
Function Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER.
Protein Name Protein Transport Protein Sec61 Subunit Beta
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-1799339
Reactome: R-HSA-9609523
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative Protein Names Protein Transport Protein Sec61 Subunit Beta protein
SEC61B protein

Information sourced from Uniprot.org

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