Human SDHAF1 protein (Recombinant) (His-Tag) (STJP018969)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SDHAF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) 30% Glycerol, 2mM DTT, 0.1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SDHAF1 |
| Gene ID | 644096 |
| Uniprot ID | SDHF1_HUMAN |
| Accession Number | NP_001036096 |
| Immunogen | Human |
| Immunogen Region | 1-115aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. |
| Protein Name | Succinate Dehydrogenase Assembly Factor 1 - MitochondrialSdh Assembly Factor 1Sdhaf1Lyr Motif-Containing Protein 8 |
| Database Links | Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Succinate Dehydrogenase Assembly Factor 1 - Mitochondrial proteinSdh Assembly Factor 1 proteinSdhaf1 proteinLyr Motif-Containing Protein 8 proteinSDHAF1 proteinLYRM8 protein |
Information sourced from Uniprot.org