| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SDCCAG8-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SDCCAG8 |
| Gene ID: | 10806 |
| Uniprot ID: | SDCG8_HUMAN |
| Immunogen Region: | Glu348-Leu680 |
| Immunogen: | Homo sapiens (Human) |
| Function | Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis. |
| Protein Name | Serologically Defined Colon Cancer Antigen 8Antigen Ny-Co-8Centrosomal Colon Cancer Autoantigen ProteinHcccap |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyCell JunctionLocated At The Distal Ends Of Both Centrioles And Colocalizes To Centrosomes Throughout The Cell CycleIsoform 2: Cytoplasm |
| Alternative Protein Names | Serologically Defined Colon Cancer Antigen 8 proteinAntigen Ny-Co-8 proteinCentrosomal Colon Cancer Autoantigen Protein proteinHcccap proteinSDCCAG8 proteinCCCAP proteinNPHP10 proteinHSPC085 protein |
Information sourced from Uniprot.org
