| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. |
| Protein Name | Syntenin-1Melanoma Differentiation-Associated Protein 9Mda-9Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18Tacip18Scaffold Protein Pbp1Syndecan-Binding Protein 1 |
| Database Links | Reactome: R-HSA-3928664Reactome: R-HSA-447043Reactome: R-HSA-5213460Reactome: R-HSA-5675482Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell JunctionFocal AdhesionAdherens JunctionCell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneNucleusMelanosomeCytoplasmCytosolCytoskeletonSecretedExtracellular ExosomeMembrane RaftMainly Membrane-AssociatedLocalized To Adherens JunctionsFocal Adhesions And Endoplasmic ReticulumColocalized With Actin Stress FibersAlso Found In The NucleusIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvAssociated To The Plasma Membrane In The Presence Of Fzd7 And Phosphatidylinositol 45-Bisphosphate (Pip2) |
| Alternative Protein Names | Syntenin-1 proteinMelanoma Differentiation-Associated Protein 9 proteinMda-9 proteinPro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18 proteinTacip18 proteinScaffold Protein Pbp1 proteinSyndecan-Binding Protein 1 proteinSDCBP proteinMDA9 proteinSYCL protein |
Information sourced from Uniprot.org
