| Post Translational Modifications | Ubiquitinated by NEDD4L.which promotes its endocytosis. Does not seem to be ubiquitinated by NEDD4 or WWP2. Phosphorylation at Ser-1503 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents (Probable). Regulated through phosphorylation by CaMK2D. Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 868) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. N-glycosylated at Asn-318, probably hinders potential interaction with regulatory subunits. |
| Function | Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.5 is the predominant sodium channel expressed in myocardial cells and it is responsible for the initial upstroke of the action potential in cardiac myocytes, thereby initiating the heartbeat. Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2. |
| Protein Name | Sodium Channel Protein Type 5 Subunit AlphaSodium Channel Protein Cardiac Muscle Subunit AlphaSodium Channel Protein Type V Subunit AlphaVoltage-Gated Sodium Channel Subunit Alpha Nav1.5Hh1 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear RegionSarcolemmaT-TubuleCell JunctionRangrf Promotes Trafficking To The Cell MembraneColocalizes With Pkp2 At Intercalated Disks In The Heart |
| Alternative Protein Names | Sodium Channel Protein Type 5 Subunit Alpha proteinSodium Channel Protein Cardiac Muscle Subunit Alpha proteinSodium Channel Protein Type V Subunit Alpha proteinVoltage-Gated Sodium Channel Subunit Alpha Nav1.5 proteinHh1 proteinSCN5A protein |
Information sourced from Uniprot.org
