Human SCG3 protein (Recombinant) (His-Tag) (STJP018318)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human SCG3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCG3 |
| Gene ID | 29106 |
| Uniprot ID | SCG3_HUMAN |
| Accession Number | NP_037375 |
| Immunogen | Human |
| Immunogen Region | 20-468aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in urine (at protein level). Expressed in brain, heart, kidney, liver and skeletal muscle. |
| Post Translational Modifications | O-glycosylated. |
| Function | Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. |
| Protein Name | Secretogranin-3Secretogranin IiiSgiii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSecretory Vesicle MembranePeripheral Membrane ProteinSecretedAssociated With The Secretory Granule Membrane Through Direct Binding To Cholesterol-Enriched Lipid Rafts |
| Alternative Protein Names | Secretogranin-3 proteinSecretogranin Iii proteinSgiii proteinSCG3 proteinUNQ2502 proteinPRO5990 protein |
Information sourced from Uniprot.org