Human SAE1 protein (Recombinant) (N-His) (STJP009397)

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STJP009397
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SAE1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SAE1
Gene ID: 10055
Uniprot ID: SAE1_HUMAN
Immunogen Region: Met1-Lys346
Immunogen: Homo sapiens (Human)
Function The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Protein Name Sumo-Activating Enzyme Subunit 1
Ubiquitin-Like 1-Activating Enzyme E1a Cleaved Into - Sumo-Activating Enzyme Subunit 1 - N-Terminally Processed
Database Links Reactome: R-HSA-3065676
Reactome: R-HSA-3065678
Cellular Localisation Nucleus
Alternative Protein Names Sumo-Activating Enzyme Subunit 1 protein
Ubiquitin-Like 1-Activating Enzyme E1a Cleaved Into - Sumo-Activating Enzyme Subunit 1 - N-Terminally Processed protein
SAE1 protein
AOS1 protein
SUA1 protein
UBLE1A protein

Information sourced from Uniprot.org