Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
Protein Name | Sumo-Activating Enzyme Subunit 1Ubiquitin-Like 1-Activating Enzyme E1a Cleaved Into - Sumo-Activating Enzyme Subunit 1 - N-Terminally Processed |
Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678 |
Cellular Localisation | Nucleus |
Alternative Protein Names | Sumo-Activating Enzyme Subunit 1 proteinUbiquitin-Like 1-Activating Enzyme E1a Cleaved Into - Sumo-Activating Enzyme Subunit 1 - N-Terminally Processed proteinSAE1 proteinAOS1 proteinSUA1 proteinUBLE1A protein |
Information sourced from Uniprot.org