Human RYK protein (Recombinant) (N-His) (STJP004589)

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STJP004589
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RYK-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RYK
Gene ID: 6259
Uniprot ID: RYK_HUMAN
Immunogen Region: Leu308-Pro568
Immunogen: Homo sapiens (Human)
Post Translational Modifications Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
Function May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
Protein Name Tyrosine-Protein Kinase Ryk
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4086400
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Nucleus
Cytoplasm
In Cells That Have Undergone Neuronal Differentiation
The C-Terminal Cleaved Part Is Translocated From The Cytoplasm To The Nucleus
Alternative Protein Names Tyrosine-Protein Kinase Ryk protein
RYK protein
JTK5A protein

Information sourced from Uniprot.org

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