Human RUVBL2 protein (Recombinant) (N-His) (STJP007522)

SKU:
STJP007522
£328.50 - £1,437.50
Free Shipping
Processing The item has been added

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RUVBL2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RUVBL2
Gene ID: 10856
Uniprot ID: RUVB2_HUMAN
Immunogen Region: Gln49-Ser463
Immunogen: Homo sapiens (Human)
Function Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity.hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes. May play a role in regulating the composition of the U5 snRNP complex.
Protein Name Ruvb-Like 2
48 Kda Tata Box-Binding Protein-Interacting Protein
48 Kda Tbp-Interacting Protein
51 Kda Erythrocyte Cytosolic Protein
Ecp-51
Ino80 Complex Subunit J
Repressing Pontin 52
Reptin 52
Tip49b
Tip60-Associated Protein 54-Beta
Tap54-Beta
Database Links Reactome: R-HSA-171319
Reactome: R-HSA-3214847
Cellular Localisation Nucleus Matrix
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Dynein Axonemal Particle
Mainly Localized In The Nucleus
Associated With Nuclear Matrix Or In The Nuclear Cytosol
Although It Is Also Present In The Cytoplasm And Associated With The Cell Membranes
Alternative Protein Names Ruvb-Like 2 protein
48 Kda Tata Box-Binding Protein-Interacting Protein protein
48 Kda Tbp-Interacting Protein protein
51 Kda Erythrocyte Cytosolic Protein protein
Ecp-51 protein
Ino80 Complex Subunit J protein
Repressing Pontin 52 protein
Reptin 52 protein
Tip49b protein
Tip60-Associated Protein 54-Beta protein
Tap54-Beta protein
RUVBL2 protein
INO80J protein
TIP48 protein
TIP49B protein
CGI-46 protein

Information sourced from Uniprot.org