| Function | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity.hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation. May be able to bind plasminogen at cell surface and enhance plasminogen activation. |
| Protein Name | Ruvb-Like 149 Kda Tata Box-Binding Protein-Interacting Protein49 Kda Tbp-Interacting Protein54 Kda Erythrocyte Cytosolic ProteinEcp-54Ino80 Complex Subunit HNuclear Matrix Protein 238Nmp 238Pontin 52Tip49aTip60-Associated Protein 54-AlphaTap54-Alpha |
| Database Links | Reactome: R-HSA-171319Reactome: R-HSA-201722Reactome: R-HSA-3214847Reactome: R-HSA-5689603Reactome: R-HSA-5689880Reactome: R-HSA-5696394Reactome: R-HSA-606279 |
| Cellular Localisation | Nucleus MatrixNucleusNucleoplasmCytoplasmMembraneCytoskeletonMicrotubule Organizing CenterCentrosomeDynein Axonemal ParticleMainly Localized In The NucleusAssociated With Nuclear Matrix Or In The Nuclear CytosolAlthough It Is Also Present In The Cytoplasm And Associated With The Cell MembranesIn Prophase And Prometaphase It Is Located At The Centrosome And The Branching Microtubule SpindlesAfter Mitotic Nuclear Membrane Disintigration It Accumulates At The Centrosome And Sites Of Tubulin PolymerizationAs Cells Pass Through Metaphase And Into Telophase It Is Located Close To The Centrosome At The Early Phase Of Tubulin PolymerizationIn Anaphase It Accumulates At The Zone Of Tubule InterdigitationIn Telophase It Is Found At Polar Tubule OverlapAnd It Reappears At The Site Of Chromosomal Decondensation In The Daughter Cells |
| Alternative Protein Names | Ruvb-Like 1 protein49 Kda Tata Box-Binding Protein-Interacting Protein protein49 Kda Tbp-Interacting Protein protein54 Kda Erythrocyte Cytosolic Protein proteinEcp-54 proteinIno80 Complex Subunit H proteinNuclear Matrix Protein 238 proteinNmp 238 proteinPontin 52 proteinTip49a proteinTip60-Associated Protein 54-Alpha proteinTap54-Alpha proteinRUVBL1 proteinINO80H proteinNMP238 proteinTIP49 proteinTIP49A protein |
Information sourced from Uniprot.org
