| Post Translational Modifications | Phosphorylated.probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-451 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression. Isoform 3 is phosphorylated on Ser-340. |
| Function | Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation. |
| Protein Name | Runt-Related Transcription Factor 2Acute Myeloid Leukemia 3 ProteinCore-Binding Factor Subunit Alpha-1Cbf-Alpha-1Oncogene Aml-3Osteoblast-Specific Transcription Factor 2Osf-2Polyomavirus Enhancer-Binding Protein 2 Alpha A SubunitPea2-Alpha APebp2-Alpha ASl3-3 Enhancer Factor 1 Alpha A SubunitSl3/Akv Core-Binding Factor Alpha A Subunit |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8878166Reactome: R-HSA-8939246Reactome: R-HSA-8939902Reactome: R-HSA-8940973Reactome: R-HSA-8941284Reactome: R-HSA-8941326Reactome: R-HSA-8941332Reactome: R-HSA-8941333 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Runt-Related Transcription Factor 2 proteinAcute Myeloid Leukemia 3 Protein proteinCore-Binding Factor Subunit Alpha-1 proteinCbf-Alpha-1 proteinOncogene Aml-3 proteinOsteoblast-Specific Transcription Factor 2 proteinOsf-2 proteinPolyomavirus Enhancer-Binding Protein 2 Alpha A Subunit proteinPea2-Alpha A proteinPebp2-Alpha A proteinSl3-3 Enhancer Factor 1 Alpha A Subunit proteinSl3/Akv Core-Binding Factor Alpha A Subunit proteinRUNX2 proteinAML3 proteinCBFA1 proteinOSF2 proteinPEBP2A protein |
Information sourced from Uniprot.org
