Human RUNX2 protein (Recombinant) (N-His) (STJP006665)

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STJP006665
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Short Description :Recombinant-Human RUNX2-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:RUNX2
Gene ID:860
Uniprot ID:RUNX2_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Val219-Val404
Post Translational Modifications Phosphorylated.probably by MAP kinases (MAPK). Phosphorylation by HIPK3 is required for the SPEN/MINT and FGF2 transactivation during osteoblastic differentiation. Phosphorylation at Ser-451 by CDK1 promotes endothelial cell proliferation required for tumor angiogenesis probably by facilitating cell cycle progression. Isoform 3 is phosphorylated on Ser-340.
Function Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.
Protein Name Runt-Related Transcription Factor 2
Acute Myeloid Leukemia 3 Protein
Core-Binding Factor Subunit Alpha-1
Cbf-Alpha-1
Oncogene Aml-3
Osteoblast-Specific Transcription Factor 2
Osf-2
Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit
Pea2-Alpha A
Pebp2-Alpha A
Sl3-3 Enhancer Factor 1 Alpha A Subunit
Sl3/Akv Core-Binding Factor Alpha A Subunit
Database Links Reactome: R-HSA-2032785
Reactome: R-HSA-8878166
Reactome: R-HSA-8939246
Reactome: R-HSA-8939902
Reactome: R-HSA-8940973
Reactome: R-HSA-8941284
Reactome: R-HSA-8941326
Reactome: R-HSA-8941332
Reactome: R-HSA-8941333
Cellular Localisation Nucleus
Cytoplasm
Alternative Protein Names Runt-Related Transcription Factor 2 protein
Acute Myeloid Leukemia 3 Protein protein
Core-Binding Factor Subunit Alpha-1 protein
Cbf-Alpha-1 protein
Oncogene Aml-3 protein
Osteoblast-Specific Transcription Factor 2 protein
Osf-2 protein
Polyomavirus Enhancer-Binding Protein 2 Alpha A Subunit protein
Pea2-Alpha A protein
Pebp2-Alpha A protein
Sl3-3 Enhancer Factor 1 Alpha A Subunit protein
Sl3/Akv Core-Binding Factor Alpha A Subunit protein
RUNX2 protein
AML3 protein
CBFA1 protein
OSF2 protein
PEBP2A protein

Information sourced from Uniprot.org

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