| Post Translational Modifications | Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors. |
| Function | Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. |
| Protein Name | Ribosomal Protein S6 Kinase Alpha-2S6k-Alpha-290 Kda Ribosomal Protein S6 Kinase 2P90-Rsk 2P90rsk2Map Kinase-Activated Protein Kinase 1cMapk-Activated Protein Kinase 1cMapkap Kinase 1cMapkapk-1cRibosomal S6 Kinase 3Rsk-3Pp90rsk3 |
| Database Links | Reactome: R-HSA-198753Reactome: R-HSA-199920Reactome: R-HSA-2559582Reactome: R-HSA-437239Reactome: R-HSA-442742Reactome: R-HSA-444257Reactome: R-HSA-881907 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Ribosomal Protein S6 Kinase Alpha-2 proteinS6k-Alpha-2 protein90 Kda Ribosomal Protein S6 Kinase 2 proteinP90-Rsk 2 proteinP90rsk2 proteinMap Kinase-Activated Protein Kinase 1c proteinMapk-Activated Protein Kinase 1c proteinMapkap Kinase 1c proteinMapkapk-1c proteinRibosomal S6 Kinase 3 proteinRsk-3 proteinPp90rsk3 proteinRPS6KA2 proteinMAPKAPK1C proteinRSK3 protein |
Information sourced from Uniprot.org
