| Post Translational Modifications | Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation. Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade. Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11. |
| Function | Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. |
| Protein Name | Proto-Oncogene Tyrosine-Protein Kinase RosProto-Oncogene C-RosProto-Oncogene C-Ros-1Receptor Tyrosine Kinase C-Ros Oncogene 1C-Ros Receptor Tyrosine Kinase |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Proto-Oncogene Tyrosine-Protein Kinase Ros proteinProto-Oncogene C-Ros proteinProto-Oncogene C-Ros-1 proteinReceptor Tyrosine Kinase C-Ros Oncogene 1 proteinC-Ros Receptor Tyrosine Kinase proteinROS1 proteinMCF3 proteinROS protein |
Information sourced from Uniprot.org
