Human ROR2 protein (Recombinant) (C-His&Avi) {Biotin} (STJP020209)

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STJP020209-100
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Biotin
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: ROR2
Gene ID: 4920
Uniprot ID: ROR2_HUMAN
Immunogen Region: Val34-Gly403
Immunogen: Biotinylated Recombinant Human ROR2 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Val34-Gly403) of Human ROR2 fused with a His and Avi tag at the C-terminal.
Function Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
Protein Name Tyrosine-Protein Kinase Transmembrane Receptor Ror2
Neurotrophic Tyrosine Kinase - Receptor-Related 2
Database Links Reactome: R-HSA-4086400
Reactome: R-HSA-5140745
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Tyrosine-Protein Kinase Transmembrane Receptor Ror2 protein
Neurotrophic Tyrosine Kinase - Receptor-Related 2 protein
ROR2 protein
NTRKR2 protein

Information sourced from Uniprot.org