| Host: | Mammalian Cells |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human ROR1-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | ROR1 |
| Gene ID: | 4919 |
| Uniprot ID: | ROR1_HUMAN |
| Immunogen Region: | Gln30-Tyr406 |
| Immunogen: | Homo sapiens (Human) |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-HSA-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Protein Names | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 proteinNeurotrophic Tyrosine Kinase - Receptor-Related 1 proteinROR1 proteinNTRKR1 protein |
Information sourced from Uniprot.org
