Human ROR1/NTRKR1 protein (Recombinant) (N-His) (STJP007728)

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STJP007728
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ROR1/NTRKR1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ROR1
Gene ID: 4919
Uniprot ID: ROR1_HUMAN
Immunogen Region: Gln30-Tyr406
Immunogen: Homo sapiens (Human)
Function Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling.
Protein Name Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1
Neurotrophic Tyrosine Kinase - Receptor-Related 1
Database Links Reactome: R-HSA-5140745
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Alternative Protein Names Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 protein
Neurotrophic Tyrosine Kinase - Receptor-Related 1 protein
ROR1 protein
NTRKR1 protein

Information sourced from Uniprot.org

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