Human RNLS protein (Recombinant) (N-His-SUMO) (STJP005563)

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STJP005563
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RNLS-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RNLS
Gene ID: 55328
Uniprot ID: RNLS_HUMAN
Immunogen Region: Met1-Ile342
Immunogen: Homo sapiens (Human)
Function Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Protein Name Renalase
Monoamine Oxidase-C
Mao-C
Database Links Reactome: R-HSA-197264
Cellular Localisation Secreted
Alternative Protein Names Renalase protein
Monoamine Oxidase-C protein
Mao-C protein
RNLS protein
C10orf59 protein

Information sourced from Uniprot.org

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