Human RNF181 protein (Recombinant) (His-Tag) (STJP017826)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RNF181-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF181 |
| Gene ID | 51255 |
| Uniprot ID | RN181_HUMAN |
| Accession Number | NP_057578 |
| Immunogen | Human |
| Immunogen Region | 1-153aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMASYFDE HDCEPSDPEQ ETRTNMLLEL ARSLFNRMDF EDLGLVVDWD HHLPPPAAKT VVENLPRTVI RGSQAELKCP VCLLEFEEEE TAIEMPCHHL FHSSCILPWL SKTNSCPLCR YELPTDDDTY EEHRRDKARK QQQQHRLENL HGAMYT |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level). |
| Post Translational Modifications | Autoubiquitinated as part of the enzymatic reaction. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Catalyzes monoubiquitination of 26S proteasome subunit PSMC2/RPT1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf181Ring Finger Protein 181 |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Rnf181 proteinRing Finger Protein 181 proteinRNF181 proteinHSPC238 protein |
Information sourced from Uniprot.org