Human RLIM protein (Recombinant) (N-His) (STJP007928)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RLIM-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RLIM |
| Gene ID | 51132 |
| Uniprot ID | RNF12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser97-Ser370 |
Additional Info
| Function | E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. |
| Protein Name | E3 Ubiquitin-Protein Ligase RlimLim Domain-Interacting Ring Finger ProteinRing Finger Lim Domain-Binding ProteinR-LimRing Finger Protein 12Ring-Type E3 Ubiquitin Transferase RlimRenal Carcinoma Antigen Ny-Ren-43 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Rlim proteinLim Domain-Interacting Ring Finger Protein proteinRing Finger Lim Domain-Binding Protein proteinR-Lim proteinRing Finger Protein 12 proteinRing-Type E3 Ubiquitin Transferase Rlim proteinRenal Carcinoma Antigen Ny-Ren-43 proteinRLIM proteinRNF12 protein |
Information sourced from Uniprot.org