Human RLIM protein (Recombinant) (N-His) (STJP007928)

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STJP007928
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RLIM-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RLIM
Gene ID: 51132
Uniprot ID: RNF12_HUMAN
Immunogen Region: Ser97-Ser370
Immunogen: Homo sapiens (Human)
Function E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Protein Name E3 Ubiquitin-Protein Ligase Rlim
Lim Domain-Interacting Ring Finger Protein
Ring Finger Lim Domain-Binding Protein
R-Lim
Ring Finger Protein 12
Ring-Type E3 Ubiquitin Transferase Rlim
Renal Carcinoma Antigen Ny-Ren-43
Database Links Reactome: R-HSA-983168
Cellular Localisation Nucleus
Alternative Protein Names E3 Ubiquitin-Protein Ligase Rlim protein
Lim Domain-Interacting Ring Finger Protein protein
Ring Finger Lim Domain-Binding Protein protein
R-Lim protein
Ring Finger Protein 12 protein
Ring-Type E3 Ubiquitin Transferase Rlim protein
Renal Carcinoma Antigen Ny-Ren-43 protein
RLIM protein
RNF12 protein

Information sourced from Uniprot.org

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