Human Riboflavin kinase/RFP protein (Recombinant) (His-Tag) (STJP016501)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Riboflavin kinase/RFP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RFK |
| Gene ID | 55312 |
| Uniprot ID | RIFK_HUMAN |
| Accession Number | NP_060809 |
| Immunogen | Human |
| Immunogen Region | 1-162aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Detected in brain, placenta and urinary bladder. |
| Function | Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. |
| Protein Name | Riboflavin KinaseAtp -Riboflavin 5'-PhosphotransferaseFlavokinase |
| Database Links | Reactome: R-HSA-196843 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Riboflavin Kinase proteinAtp -Riboflavin 5'-Phosphotransferase proteinFlavokinase proteinRFK protein |
Information sourced from Uniprot.org