| Post Translational Modifications | Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. |
| Protein Name | Regulator Of G-Protein Signaling 2Rgs2Cell Growth-Inhibiting Gene 31 ProteinG0/G1 Switch Regulatory Protein 8 |
| Database Links | Reactome: R-HSA-416476 |
| Cellular Localisation | Isoform 1: Cell MembraneCytoplasmNucleusNucleolusIsoform 2: Cell MembraneIsoform 3: Cell MembraneIsoform 4: Cell MembraneMitochondrion |
| Alternative Protein Names | Regulator Of G-Protein Signaling 2 proteinRgs2 proteinCell Growth-Inhibiting Gene 31 Protein proteinG0/G1 Switch Regulatory Protein 8 proteinRGS2 proteinG0S8 proteinGIG31 protein |
Information sourced from Uniprot.org
