| Function | Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages.and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells.resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts. |
| Protein Name | RaftlinCell Migration-Inducing Gene 2 ProteinRaft-Linking Protein |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmMembrane RaftEndosomeEarly EndosomeTranslocates From Cytoplasm To Cell Membrane Where It Colocalizes With Poly (I:c) And Then Moves To Endosomes Where It Colocalizes With Tlr3Translocates From Cytoplasm To Cell Membrane Where It Colocalizes With Tlr4 And Then Together With Tlr4 Moves To EndosomesUpon Lipopolysaccharide Stimulation |
| Alternative Protein Names | Raftlin proteinCell Migration-Inducing Gene 2 Protein proteinRaft-Linking Protein proteinRFTN1 proteinKIAA0084 proteinMIG2 protein |
Information sourced from Uniprot.org
