| Post Translational Modifications | Phosphorylated by CDK1 at Ser-727.this phosphorylation is required for RECQL5-mediated disruption of RAD51 filaments on stalled replication forks. |
| Function | DNA helicase that plays an important role in DNA replication, transcription and repair. Probably unwinds DNA in a 3'-5' direction (Probable). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Associates also with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA. |
| Protein Name | Atp-Dependent Dna Helicase Q5Dna 3'-5' Helicase Recq5Dna Helicase - Recq-Like Type 5Recq5Recq Protein-Like 5 |
| Cellular Localisation | Isoform Beta: NucleusNucleoplasmNucleusRecruited To Sites Of Dna DamageSuch As Single-Strand Breaks And Inter-Strand Cross-LinksAnd At Stalled Replication ForksRe-Localizes From The Nucleolus Into The Nucleus After Replicative Stress And Significantly Associates With Wrn During S-PhaseIsoform Alpha: CytoplasmIsoform Gamma: Cytoplasm |
| Alternative Protein Names | Atp-Dependent Dna Helicase Q5 proteinDna 3'-5' Helicase Recq5 proteinDna Helicase - Recq-Like Type 5 proteinRecq5 proteinRecq Protein-Like 5 proteinRECQL5 proteinRECQ5 protein |
Information sourced from Uniprot.org
