Human Recoverin protein (Recombinant) (No-Tag) (STJP019751)

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STJP019751
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Short Description :Recombinant-Human Recoverin-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM EDTA, 2mM MgCl2, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:RCVRN
Gene ID:5957
Uniprot ID:RECO_HUMAN
Accession Number:NP_002894
Immunogen:Human
Immunogen Region:1-200aa
Immunogen Sequence:MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ SIYAKFFPDT DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ KLEWAFSLYD VDGNGTISKN EVLEIVMAIF KMITPEDVKL LPDDENTPEK RAEKIWKYFG KNDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKMKNA
Tissue Specificity Retina and pineal gland.
Post Translational Modifications The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present. The Ca(2+) induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca(2+) concentration is high. Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers.
Function Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light.
Protein Name Recoverin
Cancer-Associated Retinopathy Protein
Protein Car
Database Links Reactome: R-HSA-2514859
Cellular Localisation Photoreceptor Inner Segment
Cell Projection
Cilium
Photoreceptor Outer Segment
Photoreceptor Outer Segment Membrane
Lipid-Anchor
Cytoplasmic Side
Perikaryon
Primarily Expressed In The Inner Segments Of Light-Adapted Rod Photoreceptors
Approximately 10% Of Which Translocates From Photoreceptor Outer Segments Upon Light Stimulation
Targeting Of Myristoylated Protein To Rod Photoreceptor Outer Segments Is Calcium Dependent
Alternative Protein Names Recoverin protein
Cancer-Associated Retinopathy Protein protein
Protein Car protein
RCVRN protein
RCV1 protein

Information sourced from Uniprot.org

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