| Post Translational Modifications | The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present. The Ca(2+) induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca(2+) concentration is high. Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers. |
| Function | Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light. |
| Protein Name | RecoverinCancer-Associated Retinopathy ProteinProtein Car |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | Photoreceptor Inner SegmentCell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Outer Segment MembraneLipid-AnchorCytoplasmic SidePerikaryonPrimarily Expressed In The Inner Segments Of Light-Adapted Rod PhotoreceptorsApproximately 10% Of Which Translocates From Photoreceptor Outer Segments Upon Light StimulationTargeting Of Myristoylated Protein To Rod Photoreceptor Outer Segments Is Calcium Dependent |
| Alternative Protein Names | Recoverin proteinCancer-Associated Retinopathy Protein proteinProtein Car proteinRCVRN proteinRCV1 protein |
Information sourced from Uniprot.org
