Human RCCD1 protein (Recombinant) (N-His) (STJP011010)

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STJP011010
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RCCD1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RCCD1
Gene ID: 91433
Uniprot ID: RCCD1_HUMAN
Immunogen Region: Met1-Ser376
Immunogen: Homo sapiens (Human)
Function Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8.
Protein Name Rcc1 Domain-Containing Protein 1
Database Links Reactome: R-HSA-9629569
Cellular Localisation Chromosome
Colocalizes With Trimethylated 'Lys-9' Of Histone H3 (H3k9me3)
Alternative Protein Names Rcc1 Domain-Containing Protein 1 protein
RCCD1 protein

Information sourced from Uniprot.org

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