| Short Description : | Recombinant-Human RBM17-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 0.5 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBM17 |
| Gene ID: | 84991 |
| Uniprot ID: | SPF45_HUMAN |
| Accession Number: | NP_116294.1 |
| Immunogen: | Human |
| Immunogen Region: | 1-401aa |
| Immunogen Sequence: |
| Function | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. |
| Protein Name | Splicing Factor 4545 Kda-Splicing FactorRna-Binding Motif Protein 17 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Splicing Factor 45 protein45 Kda-Splicing Factor proteinRna-Binding Motif Protein 17 proteinRBM17 proteinSPF45 protein |
Information sourced from Uniprot.org