| Function | RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1. |
| Protein Name | Putative Rna-Binding Protein 15bOne-Twenty Two Protein 3Hsott3Huott3Rna-Binding Motif Protein 15b |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleNucleus EnvelopeColocalizes With Bmlf1 In The NucleusLocalized In The Nucleoplasm With A Granular Staining Pattern And Excluded From The Nucleoli |
| Alternative Protein Names | Putative Rna-Binding Protein 15b proteinOne-Twenty Two Protein 3 proteinHsott3 proteinHuott3 proteinRna-Binding Motif Protein 15b proteinRBM15B proteinOTT3 protein |
Information sourced from Uniprot.org
