| Short Description : | Recombinant-Human RBBP4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 0.5 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM EDTA |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBBP4 |
| Gene ID: | 5928 |
| Uniprot ID: | RBBP4_HUMAN |
| Accession Number: | NP_005601 |
| Immunogen: | Human |
| Immunogen Region: | 1-425aa |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMADKEA AFDDAVEERV INEEYKIWKK NTPFLYDLVM THALEWPSLT AQWLPDVTRP EGKDFSIHRL VLGTHTSDEQ NHLVIASVQL PNDDAQFDAS HYDSEKGEFG GFGSVSGKIE IEIKINHEGE VNRARYMPQN PCIIATKTPS SDVLVFDYTK HPSKPDPSGE CNPDLRLRGH QKEGYGLSWN PNLSGHLLSA SDDHTICL |
| Tissue Specificity | Expressed in neuroblastoma cells. |
| Function | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair. Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression. Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling. Component of the PRC2 complex, which promotes repression of homeotic genes during development. Component of the NURF (nucleosome remodeling factor) complex. |
| Protein Name | Histone-Binding Protein Rbbp4Chromatin Assembly Factor 1 Subunit CCaf-1 Subunit CChromatin Assembly Factor I P48 SubunitCaf-I 48 Kda SubunitCaf-I P48Nucleosome-Remodeling Factor Subunit Rbap48Retinoblastoma-Binding Protein 4Rbbp-4Retinoblastoma-Binding Protein P48 |
| Database Links | Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-1538133Reactome: R-HSA-156711Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-427389Reactome: R-HSA-5617472Reactome: R-HSA-606279Reactome: R-HSA-6804758Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69656Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9679191Reactome: R-HSA-9710421Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosomeTelomereLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Protein Names | Histone-Binding Protein Rbbp4 proteinChromatin Assembly Factor 1 Subunit C proteinCaf-1 Subunit C proteinChromatin Assembly Factor I P48 Subunit proteinCaf-I 48 Kda Subunit proteinCaf-I P48 proteinNucleosome-Remodeling Factor Subunit Rbap48 proteinRetinoblastoma-Binding Protein 4 proteinRbbp-4 proteinRetinoblastoma-Binding Protein P48 proteinRBBP4 proteinRBAP48 protein |
Information sourced from Uniprot.org
